@article{ZHANG2022, 
author = {Ling ZHANG and Jingyuan DONG and Yongde CHEN and Qian LI and Tao WU and Rui LIU and Wenjie SUI and Min ZHANG},
title = {Saponins from Sea Cucumber Residues Protect against Cyclophosphamide-Induced Immunosuppression in Mice via the Nucleotide Binding and Oligomerization Domain-Like Receptor Signaling Pathway},
year = {2022},
journal = {Food Science},
volume = {43},
number = {21},
pages = {191-202},
keywords = {sea cucumber residues, saponins, cyclophosphamide, immunomodulatory activity, nucleotide binding and oligomerization domain-like receptor},
url = {https://www.sciopen.com/article/10.7506/spkx1002-6630-20211010-089},
doi = {10.7506/spkx1002-6630-20211010-089},
abstract = {Sea cucumber is a traditional Chinese tonic with various bioactivities. This study systematically investigated the immunomodulatory effect of saponins extracted from sea cucumber residues (SCRSS) at doses of 2.5, 5.0 and 10.0 mg/(kg mb·d) on immunosuppressive mice. The results showed that SCRSS at a dose of 5.0 mg/(kg mb·d) increased the body mass, spleen index, and thymus index by 15.3%, 23.8%, and 39.8%, respectively, compared to the model control group, and it also significantly increased the phagocytic index in immunosuppressive mice (P < 0.01). Moreover, All the doses of SCRSS remarkably increased serum cytokine levels, promoted the proliferation activity of splenic lymphocytes and peritoneal macrophages. Importantly, the middle dose (5.0 mg/(kg mb·d)) of SCRSS was more effective to upregulate the expression of nucleotide binding and oligomerization domain (NOD)1, NOD2, receptor interacting protein 2 (RIP2) and nuclear factor (NF)-κB in immunosuppressive mice. Thus, SCRSS may be used as a functional food supplement to improve immunity.}
}