@article{GU2022, 
author = {Peixian GU and Huishuang YIN and Kun HU and Xiaoyong WU and Nanjing ZHONG and Juan GUO and Chao HUANG and Yong HU and Yun CHEN and Ying WANG and Fangfang WU},
title = {Preparation, Structural Characterization and Anti-proliferation Activity of Selenized Hericium erinaceus Polysaccharide},
year = {2022},
journal = {Food Science},
volume = {43},
number = {22},
pages = {68-73},
keywords = {Hericium erinaceus polysaccharide, selenization modification, structural characterization, anti-proliferative activity},
url = {https://www.sciopen.com/article/10.7506/spkx1002-6630-20220104-023},
doi = {10.7506/spkx1002-6630-20220104-023},
abstract = {In this study, Hericium erinaceus polysaccharide (HEPS, with a purity of more than 92%) was modified using a redox system consisting of Na2SeO3 and ascorbic acid (VC) to obtain selenized HEPS (HEPS-Se). The structural and physiochemical properties of HEPS-Se were investigated by atomic absorption spectrometry (AAS), Fourier transform infrared (FTIR) spectroscopy, X-ray diffractometry (XRD), scanning electron microscopy (SEM), energy-dispersive X-ray (EDX) spectroscopy, X-ray photoelectron spectroscopy (XPS), and nano-zetasizer analysis. The anti-proliferation activity of HEPS-Se on A549 human lung cancer cells and DU145 human prostate cancer cells was evaluated. Results showed that HEPS-Se had a regular spherical shape and four elements C, O, Se and Pt at a ratio of 32.92:24.74:30.46:11.87 were determined in HEPS-Se. Its selenium content was 481.79 μg/g. FTIR analysis showed that HEPS could bind to selenium nanoparticles mainly through –OH and –C=O groups. Compared with HEPS, the particle size of HEPS-Se decreased significantly and the absolute potential increased by 69.12%. Meanwhile, HEPS-Se exhibited significantly anti-proliferative effects on DU145 cells and A549 cells in a dose-dependent manner. This study provides a theoretical basis for the development of organic selenium supplements.}
}