TY  - JOUR
AU  - SUN, Ming
AU  - GU, Qihui
AU  - ZHANG, Jumei
AU  - GUO, Weipeng
AU  - WU, Huiqing
AU  - ZHANG, Youxiong
AU  - WEI, Xianhu
AU  - WU, Qingping
PY  - 2022
TI  - Determination of N-Nitrosamine Disinfection By-products in Drinking Water by Ultra-high Performance Liquid Chromatography-Triple Quadrupole Mass Spectrometry
JO  - Food Science
SN  - 1002-6630
SP  - 310
EP  - 315
VL  - 43
IS  - 2
AB  - In order to evaluate the potential risks posed by N-nitrosamines, a group of emerging disinfection by-products in drinking water, to the food and beverage industry, a method based on ultra-high performance liquid chromatography-triple quadrupole mass spectrometry (UPLC-MS/MS) was developed for the simultaneous determination of nine N-nitrosamine disinfection by-products in drinking water. The samples were extracted by solid phase extraction. The chromatographic separation was accomplished on a RRHD-C18 column with gradient elution using a mobile phase consisting of 10 mmol/L ammonium bicarbonate aqueous solution containing 0.2% formic acid and methanol. The detection was carried out using an atmospheric pressure chemical ionization (APCI) source in a multi-reaction monitoring (MRM) mode. Under optimized conditions, the calibration curves for nine N-nitrosamines were linear in a certain concentration range, with correlation coefficient greater than 0.996, and the detection limit of the developed method was 0.10–0.33 ng/L. The spiked recoveries of the method were 62.1%–118.2%, with relative standard deviation (RSD) of 2.2%–10.0%. The analysis process took 6 min. Compared with the existing methods, this method is very sensitive, fast and highly applicable, and can meet the requirements for the detection of N-nitrosamine disinfection by-products in drinking water for food and beverage production.
UR  - https://doi.org/10.7506/spkx1002-6630-20210425-351
DO  - 10.7506/spkx1002-6630-20210425-351