@article{Gao2025, 
author = {Ya Gao and Danping Wang and Shengyao Xu and Jinrui Liu and Xianbao Shi and Zhonggui He and Yinglei Zhai and Bingjun Sun and Jin Sun},
title = {Aliphatic alcohols-based modification strategy to balance efficacy and safety of cabazitaxel prodrug nanoassemblies},
year = {2025},
journal = {Nano Research},
volume = {18},
number = {11},
pages = {94907933},
keywords = {cabazitaxel, self-assembly ability, prodrug-based nanoassemblies, chemotherapeutic drugs, aliphatic alcohols},
url = {https://www.sciopen.com/article/10.26599/NR.2025.94907933},
doi = {10.26599/NR.2025.94907933},
abstract = {Prodrug-based nanoassemblies have emerged as advanced carrier-free nanomedicines. These prodrugs typically consist of drug modules, response modules, and modification modules. The general role of modification modules is to modulate the self-assembly ability of the prodrugs. How to optimize the structure of modification modules for balanced efficacy and safety of high-toxicity chemotherapeutic drugs deserves to be further investigated. In this study, a modification strategy of aliphatic alcohols with various chain lengths (SC4, SC8, SC12, SC16 and SC20) was carried out to design five cabazitaxel (CBZ) prodrugs. Among them, CBZ-SC NPs with shorter chain length (SC4 and SC8) showed poor self-assembly stability. CBZ-SC12 NPs also failed to remain stable while the other two CBZ-SC NPs exhibited good stability. In turn, the drug release rate was hindered by the increasing chain length. CBZ-SC12 NPs caused kidney damage due to their high redox-sensitivity and rapid release rate during circulation. By contrast, CBZ-SC NPs with longer chain length (SC16 and SC20) not only demonstrated superior stability with improved pharmacokinetic behavior, but also might solve the dilemma of dose-related toxicity caused by CBZ. Overall, these findings emphasized the importance of chain length in modification module to modulate the efficacy and safety of CBZ prodrug nanoassemblies.}
}