@article{WANG2025, 
author = {Xiao WANG and Shang XIA and Yan LIU and Yu'e YANG and Hong LI},
title = {Regenerative endodontic procedures for a prematurely erupted maxillary premolar with immature roots and chronic apical periodontitis: a case report and literature review},
year = {2025},
journal = {Journal of Prevention and Treatment for Stomatological Diseases},
volume = {33},
number = {8},
pages = {666-671},
keywords = {premature eruption, young permanent teeth, Nolla stage Ⅶ, premolar, chronic periapical periodontitis, regenerative endodontic procedures, root canal disinfection, coronal sealing},
url = {https://www.sciopen.com/article/10.12016/j.issn.2096-1456.202550084},
doi = {10.12016/j.issn.2096-1456.202550084},
abstract = {ObjectiveTo investigate treatment strategies for chronic periapical periodontitis in prematurely erupted premolars and provide guidance for managing pulp and periapical diseases in young permanent teeth with immature roots.MethodsA regenerative endodontic procedure (REP) was performed on a prematurely erupted maxillary left first premolar (tooth 24) at Nolla stage Ⅶ with chronic apical periodontitis, following standardized protocols including root canal irrigation, disinfection, and coronal sealing. The case was followed up, and a literature review was conducted.ResultsClinical resolution of symptoms was observed on tooth 24, with sustained root development. After a 20-month follow-up, the tooth had restored biological function. Literature synthesis revealed that periapical infections in prematurely erupted permanent teeth predominently arise from pulp exposure and bacterial infection, with retrograde infection being rare. For young permanent teeth with necrotic pulp, regenerative endodontic procedures has been established as the treatment of choice to promote apical closure and root maturation. The critical steps of regenerative endodontic procedures include thorough disinfection, induced bleeding to form a fibrin scaffold, and coronal sealing to facilitate stem cell recruitment and differentiation.ConclusionRegenerative endodontic procedures represents an effective and viable treatment option for prematurely erupted young permanent teeth with chronic periapical periodontitis.}
}