@article{HAN2025, 
author = {Liguang HAN and Wanxia LIANG and Wenshuo WANG and Jie XIAO and Chi-Tang HO and Muwen LÜ},
title = {Regulatory Effect and Mechanism of Capsaicin on the Circadian Rhythm of Hepatic and Pancreatic Glucose Metabolism in High-Fructose and High-Fat Diet-Fed Mice},
year = {2025},
journal = {Food Science},
volume = {46},
number = {15},
pages = {212-223},
keywords = {circadian clock, glucose metabolism, insulin resistance, capsaicin, fecal metabolites},
url = {https://www.sciopen.com/article/10.7506/spkx1002-6630-20250121-154},
doi = {10.7506/spkx1002-6630-20250121-154},
abstract = {In this study, the modulatory effect of capsaicin (CAP) on the circadian rhythm of glucose metabolism in the liver and pancreas of mice fed a high-fructose and high-fat diet (HFFD) was investigated. Our results indicated that CAP alleviated HFFD-induced insulin resistance and increased liver glycogen content in mice. In addition, it restored the rhythmic expressions of circadian clock genes and glucose metabolism-related genes in the liver and pancreas, alleviated pancreatic dysfunction and reprogrammed the fecal metabolic profile of HFFD-fed mice. These findings suggested that CAP might work as a functional food ingredient to improve the circadian rhythm of glucose metabolism, providing a more effective dietary intervention strategy for the prevention of metabolic disorders and circadian rhythm disturbances.}
}