@article{Zhou2025, 
author = {Kexue Zhou and Chengxiang Yang and Yan Li},
title = {Multi-omics in colorectal cancer liver metastasis: applications and research advances},
year = {2025},
journal = {Cancer Biology & Medicine},
volume = {22},
number = {6},
pages = {618-638},
keywords = {Colorectal cancer liver metastasis, genomics, transcriptomics, epigenomics, proteomics, metabolomics, microbiomics},
url = {https://www.sciopen.com/article/10.20892/j.issn.2095-3941.2025.0066},
doi = {10.20892/j.issn.2095-3941.2025.0066},
abstract = {Colorectal cancer (CRC) is a common malignant tumor with a high mortality rate worldwide. Advanced CRC often leads to liver metastasis, which has a poor prognosis, highlighting the need to investigate the underlying mechanisms. Omics, encompassing genomics, epigenomics, transcriptomics, proteomics, metabolomics, and microbiomics, enables comprehensive molecular analysis of cells and tissues. Tumor-omics research has advanced rapidly, with growing attention on CRC-related omics. However, systematic reviews on omics research specific to colorectal cancer liver metastasis (CRLM) are limited. This review summarizes the current status and progress of multi-omics research on CRLM and discusses the application of multi-omics technologies in basic research and the significant clinical implications.}
}