TY  - JOUR
AU  - Zhou, Kexue
AU  - Yang, Chengxiang
AU  - Li, Yan
PY  - 2025
TI  - Multi-omics in colorectal cancer liver metastasis: applications and research advances
JO  - Cancer Biology & Medicine
SN  - 2095-3941
SP  - 618
EP  - 638
VL  - 22
IS  - 6
AB  - Colorectal cancer (CRC) is a common malignant tumor with a high mortality rate worldwide. Advanced CRC often leads to liver metastasis, which has a poor prognosis, highlighting the need to investigate the underlying mechanisms. Omics, encompassing genomics, epigenomics, transcriptomics, proteomics, metabolomics, and microbiomics, enables comprehensive molecular analysis of cells and tissues. Tumor-omics research has advanced rapidly, with growing attention on CRC-related omics. However, systematic reviews on omics research specific to colorectal cancer liver metastasis (CRLM) are limited. This review summarizes the current status and progress of multi-omics research on CRLM and discusses the application of multi-omics technologies in basic research and the significant clinical implications.
UR  - https://doi.org/10.20892/j.issn.2095-3941.2025.0066
DO  - 10.20892/j.issn.2095-3941.2025.0066