@article{Wang2025, 
author = {Haoyu Wang and Chen Chen and Yufeng Sun and Geoffrey I.N. Waterhouse and Zhixiang Xu},
title = {Sandwich-type photoelectrochemical aptasensor based on Cu2MoS4/CdS/In2S3 nanoclusters for highly sensitive detection of zearalenone in foods},
year = {2025},
journal = {Food Science and Human Wellness},
keywords = {Zearalenone, Photoelectrochemical aptasensor, Competitive light absorption, Ultrasenstive detection},
url = {https://www.sciopen.com/article/10.26599/FSHW.2025.9250702},
doi = {10.26599/FSHW.2025.9250702},
abstract = {In this study, a sandwich-type photoelectrochemical (PEC) aptasensor based on Cu2MoS4/CdS/In2S3 nanoclusters was resoundingly exploited for the detection of zearalenone (ZEN) in foods. Specifically, indium tin oxide (ITO) coated glass slides were decorated with Cu2MoS4/CdS/In2S3 and then ZEN aptamer-1 to create photoactive substrates (Cu2MoS4/CdS/In2S3-Apt1), with MoS2 quantum dots modified with ZEN aptamer-2 (MoS2 QDs-Apt2) serving as a PEC signal quencher. In the presence of ZEN, the close proximity of MoS2 QDs-Apt2 to Cu2MoS4/CdS/In2S3-Apt1 created competition for light absorption and electron donors, resulting in a decrease in photocurrent but boosted detection sensitivity. The aptasensor that was constructed demonstrated a broad linear range (10-5-103 ng/mL) with a limit of detection (LOD) as low as 2.38 fg/mL. In addition, the aptasensor offered excellent stability, anti-interference properties, and practicality for ZEN detection in real food samples. This work offers a new approach for the ultrasensitive detection of harmful mycotoxins in foods.}
}