@article{Wang2024, 
author = {Xiao-Yan Wang and Hong-Wei Deng and Jian Yang and Xue-Mei Zhu and Feng-Ling Xiang and Jing Tu and Ming-Xue Huang and Yun Wang and Jin-Hua Gan and Wei-Hua Yang},
title = {The optimal atropine concentration for myopia control in Chinese children: a systematic review and network Meta-analysis},
year = {2024},
journal = {International Journal of Ophthalmology},
volume = {17},
number = {6},
pages = {1128-1137},
keywords = {atropine, China, children and adolescents, myopia, network Meta-analysis},
url = {https://www.sciopen.com/article/10.18240/ijo.2024.06.19},
doi = {10.18240/ijo.2024.06.19},
abstract = {AIMTo figure out whether various atropine dosages may slow the progression of myopia in Chinese kids and teenagers and to determine the optimal atropine concentration for effectively slowing the progression of myopia.METHODSA systematic search was conducted across the Cochrane Library, PubMed, Web of Science, EMBASE, CNKI, CBM, VIP, and Wanfang database, encompassing literature on slowing progression of myopia with varying atropine concentrations from database inception to January 17, 2024. Data extraction and quality assessment were performed, and a network Meta-analysis was executed using Stata version 14.0 Software. Results were visually represented through graphs.RESULTSFourteen papers comprising 2475 cases were included; five different concentrations of atropine solution were used. The network Meta-analysis, along with the surface under the cumulative ranking curve (SUCRA), showed that 1% atropine (100%)>0.05% atropine (74.9%) >0.025% atropine (51.6%)>0.02% atropine (47.9%)>0.01% atropine (25.6%)>control in refraction change and 1% atropine (98.7%)>0.05% atropine (70.4%)>0.02% atropine (61.4%)>0.025% atropine (42%)>0.01% atropine (27.4%)>control in axial length (AL) change.CONCLUSIONIn Chinese children and teenagers, the five various concentrations of atropine can reduce the progression of myopia. Although the network Meta-analysis showed that 1% atropine is the best one for controlling refraction and AL change, there is a high incidence of adverse effects with the use of 1% atropine. Therefore, we suggest that 0.05% atropine is optimal for Chinese children to slow myopia progression.}
}