@article{Gao2024, 
author = {Ying Gao and Rong-Xin Lu and Yun Tang and Xin-Yi Yang and Hu Meng and Chang-Lin Zhao and Yi-Lu Chen and Feng Yan and Qian Cao},
title = {Systemic immune-inflammation index, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio in patients with type 2 diabetes at different stages of diabetic retinopathy},
year = {2024},
journal = {International Journal of Ophthalmology},
volume = {17},
number = {5},
pages = {877-882},
keywords = {diabetic retinopathy, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, systemic immune-inflammation index},
url = {https://www.sciopen.com/article/10.18240/ijo.2024.05.12},
doi = {10.18240/ijo.2024.05.12},
abstract = {AIMTo investigate systemic immune-inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) levels in patients with type 2 diabetes at different stages of diabetic retinopathy (DR).METHODSThis retrospective study included 141 patients with type 2 diabetes mellitus (DM): 45 without diabetic retinopathy (NDR), 47 with non-proliferative diabetic retinopathy (NPDR), and 49 with proliferative diabetic retinopathy (PDR). Complete blood counts were obtained, and NLR, PLR, and SII were calculated. The study analysed the ability of inflammatory markers to predict DR using receiver operating characteristic (ROC) curves. The relationships between DR stages and SII, PLR, and NLP were assessed using multivariate logistic regression.RESULTSThe average NLR, PLR, and SII were higher in the PDR group than in the NPDR group (P=0.011, 0.043, 0.009, respectively); higher in the NPDR group than in the NDR group (P<0.001 for all); and higher in the PDR group than in the NDR group (P<0.001 for all). In the ROC curve analysis, the NLR, PLR, and SII were significant predictors of DR (P<0.001 for all). The highest area under the curve (AUC) was for the PLR (0.929 for PLR, 0.925 for SII, and 0.821 for NLR). Multivariate regression analysis indicated that NLR, PLR, and SII were statistically significantly positive and independent predictors for the DR stages in patients with DM [odds ratio (OR)=1.122, 95% confidence interval (CI): 0.200–2.043, P<0.05; OR=0.038, 95%CI: 0.018–0.058, P<0.05; OR=0.007, 95%CI: 0.001–0.01, P<0.05, respectively).CONCLUSIONThe NLR, PLR, and SII may be used as predictors of DR.}
}