@article{Lin2024, 
author = {Hai-Shuang Lin and Xiao-Ping Xu and Xuan-Li Zheng and Ji-Bing Wang and Su-Jie Fan and Zuo-Hong Wu and Su-Mian Cheng and Li-Jun Zhao and Qin-Hua Cai and Shao-Dan Zhang and Shan-Shan Liu and Ai-Guo Lyu and Ying Zhang and Hong Chen and Dan-Ni Jiang and Wu-Liang Li and Nathan Congdon and Clement C Tham and Ming-Guang He and Yuan-Bo Liang},
title = {Malignant glaucoma treated by low-dose laser cycloplasty: a 1-year multicenter prospective non-comparative study},
year = {2024},
journal = {International Journal of Ophthalmology},
volume = {17},
number = {7},
pages = {1248-1254},
keywords = {anterior chamber reformation, intraocular pressure, low-dose laser cycloplasty, malignant glaucoma, anatomical success},
url = {https://www.sciopen.com/article/10.18240/ijo.2024.07.08},
doi = {10.18240/ijo.2024.07.08},
abstract = {AIMTo report a one-year clinical outcomes of low-dose laser cycloplasty (LCP) among malignant glaucoma patients.METHODSIn this prospective, multicenter, non-comparative clinical study, participants with malignant glaucoma were recruited and underwent LCP at eight ophthalmic centers in China. Patients were followed up at 1wk, 1, 3, 6, and 12mo. Intraocular pressure (IOP), number of glaucoma medications, anterior chamber depth (ACD), and complications were recorded. Anatomical success was defined as the reformation of the anterior chamber based on slit-lamp biomicroscopy. Recurrence was defined by the presence of a shallow or flat anterior chamber after initial recovery from treatment.RESULTSA total of 34 eyes received LCP. Mean IOP and medications decreased from 36.1±11.5 mm Hg with 3.3±1.5 glaucoma medications pre-treatment to 20.9±9.8 mm Hg (P<0.001) with 2.9±1.6 medications (P=0.046) at 1d, and 17.4±6.7 mm Hg (P<0.001) with 1.3±1.7 medications (P<0.001) at 12mo. The ACD increased from 1.1±0.8 mm at baseline to 1.7±1.0 mm and to 2.0±0.5 mm at 1d and 12mo, respectively. A total of 32 (94.1%) eyes achieved initial anatomical success. During follow-up, 2 (5.9%) eyes failed and 8 (23.5%) eyes relapsed, yielding a 12-month anatomical success rate of 64.3%. Complications including anterior synechia (8.82%), choroidal/ciliary detachment (5.88%) and hypopyon (2.94%) were observed within 1wk.CONCLUSIONLCP is simple, safe, and effective in reforming the anterior chamber in malignant glaucoma.}
}