@article{LI2025, 
author = {Yi LI and Xinxin REN and Qin WANG and Xiaoyun HE},
title = {Research Progress in Lactoferrin’s Role in Alleviating Intestinal Barrier Dysfunction},
year = {2025},
journal = {Food Science},
volume = {46},
number = {2},
pages = {317-326},
keywords = {lactoferrin, intestinal barrier, physiological activity, gut microorganisms},
url = {https://www.sciopen.com/article/10.7506/spkx1002-6630-20231113-100},
doi = {10.7506/spkx1002-6630-20231113-100},
abstract = {The intestinal barrier plays a crucial role in maintaining homeostasis in the body. When the intestinal mucosa is damaged, the tight junctions between intestinal cells are disrupted, and the intestinal flora becomes imbalanced, a variety of diseases can arise. Natural active proteins are pivotal in the repair of the intestinal barrier. Lactoferrin, a glycoprotein abundant in mammalian milk, exhibits a range of biological functions such as antioxidant, anti-inflammatory and antibacterial functions. Numerous studies have shown that lactoferrin elevates the levels of intestinal tight junction proteins, promotes the growth and development of intestinal cells, down-regulates the expression of inflammatory factors, regulates the immune response and intestinal microbial diversity, and contributes to the maintenance of intestinal barrier homeostasis. In this paper, a review on the alleviation of intestinal barrier dysfunction by lactoferrin is conducted, aiming to gain a better understanding of the mechanisms underlying lactoferrin’s role in alleviating intestinal injury and to provide insights for the development of lactoferrin-based interventions in intestinal diseases.}
}