@article{Song2025, 
author = {Yixin Song and Kexin Zhang and Jingwen Zhang and Qinying Li and Na Huang and Yujie Ma and Ningning Hou and Fang Han and Chengxia Kan and Xiaodong Sun},
title = {Epigenetic regulation of nuclear receptors: Implications for endocrine-related diseases and therapeutic strategies},
year = {2025},
journal = {Genes & Diseases},
volume = {12},
number = {4},
pages = {101481},
keywords = {Androgen receptor, Breast cancer, DNA methylation, Epigenetic modulation, Estrogen receptor, Histone modification, Nuclear receptor},
url = {https://www.sciopen.com/article/10.1016/j.gendis.2024.101481},
doi = {10.1016/j.gendis.2024.101481},
abstract = {The expression and function of the receptor are controlled by epigenetic changes, such as DNA methylation, histone modification, and noncoding RNAs. These modifications play a pivotal role in receptor activity and can lead to or exacerbate endocrine-related diseases. This review examines the epigenetic alterations of nuclear receptors and their significant impact on conditions such as diabetes, thyroid disorders, and endocrine-related tumors. It highlights current therapies targeting these epigenetic mechanisms, including gene editing, epigenetic drugs, and various other therapeutic approaches. This review offers fresh insight into the mechanisms of endocrine-associated disorders, highlighting the latest progress in the development of novel epigenetic therapies that can be used to address receptor–endocrine interactions.}
}