TY  - JOUR
AU  - Zhang, Wenhui
AU  - Xu, Yaqi
AU  - Cui, Jingxuan
AU  - Xue, Yingshuang
AU  - Zhang, Lijie
AU  - Wu, Wenjuan
AU  - Wang, Chong
AU  - Zhang, Hui
PY  - 2024
TI  - Development of the A&GBE base editor for efficiently generating abundant genetic variation in rice
JO  - The Crop Journal
SN  - 2095-5421
SP  - 1801
EP  - 1805
VL  - 12
IS  - 6
AB  - We have developed a dual base editor, rA&GBE, by fusing adenine and glycosylase base editors. It can induce up to eight types of mutations in T0-generation rice, including single-base conversion, simultaneous multiple-base conversions, and InDels, using a single guide RNA. A-to-G and C-to-G/T conversions occur simultaneously on the same DNA strand. The rA&GBE system may prove useful for crop improvement and in planta direct evolution.
UR  - https://doi.org/10.1016/j.cj.2024.08.009
DO  - 10.1016/j.cj.2024.08.009