@article{Wang2026, 
author = {Jin Wang and Xiaofei Li and Zhixiang Xu and Longhua Xu},
title = {One-pot room temperature synthesis of CsPbBr3 quantum dots-embedded molecularly imprinted polymer nanoparticles for sensitive sensing of ciprofloxacin},
year = {2026},
journal = {Food Science and Human Wellness},
volume = {15},
number = {10},
pages = {9250607},
keywords = {All-inorganic perovskites quantum dots, Fluorescent turn-off sensor, Molecular imprinted polymer, Ciprofloxacin},
url = {https://www.sciopen.com/article/10.26599/FSHW.2025.9250607},
doi = {10.26599/FSHW.2025.9250607},
abstract = {All-inorganic cesium lead halide perovskites quantum dots (PQDs) have emerged as promising candidates for developing high-performance sensing platforms, owing to their superior electrical and photophysical properties. However, the high-temperature synthesis and instability in polar solvent limit their practical application in water-phase environments, such as food safety monitoring. Herein, a versatile one-pot room temperature approach for the synthesis of molecular imprinted polymer-coated CsPbBr3 quantum dots (CsPbBr3@MIP) sol-gel method was presented. A highly luminescent PQDs was fabricated via a room temperature reaction and employed as a signal transducer, while the in-situ grown molecularly imprinted polymers (MIPs) acted as both protective shells and recognition units. Compared to bare CsPbBr3 quantum dots, CsPbBr3@MIP nanocomposites demonstrated an enhanced fluorescence stability and selectivity for ciprofloxacin (CIP). The green fluorescence (FL) emission of CsPbBr3@MIP at 520 nm is quenched by CIP, enabling the development of a turn-off sensor for CIP detection. Under optimized conditions, the fluorescence intensity of the CsPbBr3@MIP showed a strong linear correlation with CIP concentration in a wide range of 0.05–10.00 mg/L, and the limit of detection was as low as 0.03 mg/L. The relative standard deviation of 5 replicate determination for 1.0 mg/L CIP was 3.5%. Electron transfer between CIP and CsPbBr3@MIP was asserted to be the primary FL quenching mechanism. The CsPbBr3@MIP sensor was successfully applied to detect CIP in fresh fishes, yielding satisfactory recoveries of 91.3%–111.5% and high accuracy verified with the standard HPLC method.}
}