@article{Li2025, 
author = {Ping Li and Shan Zhang and Xinyue Yang and Xinyi Wang and Zixuan Xie and Hongming He and Fuxing Sun and Jia Liu and Jiyang Li},
title = {Integrating Au@MOF@COF nanocomposites for electrochemical aptasensing of trace oxytetracycline},
year = {2025},
journal = {Nano Research},
volume = {18},
number = {10},
pages = {94907590},
keywords = {covalent organic framework, metal–organic framework, electrochemical aptasensor, oxytetracycline, multivariate nanocomposite},
url = {https://www.sciopen.com/article/10.26599/NR.2025.94907590},
doi = {10.26599/NR.2025.94907590},
abstract = {Developing efficient electrochemical aptasensors is one of the effective methods to address the thorny issue of antibiotic abuse that poses a threat to human health. Functional materials are crucial for improving detection performance. Combining the advantages of gold (Au) nanoparticles, metal–organic frameworks (MOFs), and covalent organic frameworks (COFs), a multivariate Au@MOF@COF nanocomposite was designed and synthesized to immobilize aptamers for electrochemical aptasensing of trace oxytetracycline (1.0 × 10−4–0.1 ng·mL−1) with great sensitivity, good repeatability, fine stability, and remarkable selectivity. Especially, quantitative detection and analysis of oxytetracycline can be achieved in real milk samples using this aptasensor.}
}