@article{KA2025, 
author = {HYE IN KA and SE HWAN MUN and SORA HAN and YOUNG YANG},
title = {Targeting myeloid-derived suppressor cells in the tumor microenvironment: potential therapeutic approaches for osteosarcoma},
year = {2025},
journal = {Oncology Research},
volume = {33},
number = {3},
pages = {519-531},
keywords = {Immune cells, Tumor microenvironment (TME), Bone malignancy, Myeloid-derived suppressor cells (MDSC)},
url = {https://www.sciopen.com/article/10.32604/or.2024.056860},
doi = {10.32604/or.2024.056860},
abstract = {Osteosarcoma is a bone malignancy characterized by strong invasiveness and rapid disease progression. The tumor microenvironment of osteosarcoma contains various types of immune cells, including myeloid-derived suppressor cells, macrophages, T cells, and B cells. Imbalances of these immune cells can promote the proliferation and metastasis of osteosarcoma. Recent studies have indicated a substantial increase in the levels of myeloid-derived suppressor cells, an immune cell associated with immunosuppressive and pro-cancer effects, in the peripheral blood of patients with osteosarcoma. Moreover, the levels of the pro-inflammatory cytokine interleukin 18 are positively correlated with those of myeloid-derived suppressor cells in the peripheral blood of animal models of osteosarcoma. In this review, we explore the function of myeloid-derived suppressor cells in osteosarcoma based on the clinical diagnoses of patients with osteosarcoma and discuss future therapeutic approaches for targeting osteosarcoma. Targeting myeloid-derived suppressor cells represents a promising approach to improving the prognosis and survival rates of patients with osteosarcoma.}
}