@article{Xing2025, 
author = {Songzhu Xing and Zhong Zhang and Xujiao Ma and Mingxia Zhang and Xiao Feng and Yiwei Liu},
title = {Defective polyoxometalate-based MOFs enable one-pot two-step tandem catalysis: Direct conversion of alkenes to amino alcohols},
year = {2025},
journal = {Nano Research},
volume = {18},
number = {6},
pages = {94907471},
keywords = {polyoxometalate, metal–organic frameworks (MOFs), defect, tandem catalysis, dual-active sites},
url = {https://www.sciopen.com/article/10.26599/NR.2025.94907471},
doi = {10.26599/NR.2025.94907471},
abstract = {The conventional synthesis of fine chemicals through multi-step independent reactions frequently necessitates intermittent catalyst substitution and laborious intermediate purification, posing significant challenges to process efficiency and energy sustainability. Herein, we developed a polyoxometalate (POM)-mediated defect engineering strategy to construct a spatially isolated but functionally coupled oxidation–amination dual-active sites by confining H5PV2Mo10O40 ({PV2Mo10}) in UiO-66 ({PV2Mo10}-0.1@UiO-66), achieving a one-pot two-step tandem conversion of alkenes to amino alcohols. The complete conversion process begins with {PV2Mo10}-catalyzed highly selective epoxidation of the alkenes (step A), followed by the in situ ring-opening amination of the epoxide intermediate by direct addition of the amine under the catalysis of the defective sites on UiO-66, without catalyst replacement and intermediate separation. Spectroscopic and catalytic performance analysis confirmed that the {PV2Mo10}-0.1@UiO-66 with dual-active sites has continuous reaction and multi-cycle structural stability. Based on the rich functionality of POMs and metal–organic frameworks (MOFs), their diverse assembly will provide a modular design platform for catalyst design aimed at tandem reactions.}
}