@article{Chen2023, 
author = {Qiwen Chen and Yunhao Fan and Shu Dong and Ping Han and Tian Xie and Chenchen Wang and Xiaoqin Zeng and Wenjiang Ding and Zhiqiang Meng and Leyun Wang},
title = {A highly degradable Mg-Al-Ca alloy with superior anti-tumor efficacy},
year = {2023},
journal = {Journal of Magnesium and Alloys},
volume = {11},
number = {11},
pages = {4206-4217},
keywords = {Magnesium, Hydrogen, Cancer, Biodegradation, Hyperthermia therapy},
url = {https://www.sciopen.com/article/10.1016/j.jma.2023.07.018},
doi = {10.1016/j.jma.2023.07.018},
abstract = {Molecule hydrogen (H2) has been used to suppress tumor growth. To employ the H2 therapy, it is necessary to use a proper agent for continuous generation of H2. As a biodegradable metal, magnesium (Mg) generates H2 in an aqueous environment, but the H2 release rate is still too low. Here, we design a Mg-Al-Ca (AX) alloy that degrades very rapidly due to the presence of a secondary phase Al2Ca. Having a reduction potential much higher than Mg and any other Mg-based secondary phases, Al2Ca accelerates the corrosion of the Mg matrix by a micro-galvanic process. Al2Ca also enhances the strength and ductility of the AX alloy. AX alloy rods show better anti-tumor efficacy than pure Mg rods in vivo. Moreover, implanted AX alloy rods can be heated under an alternating magnetic field to suppress large-size tumors. This work suggests that the H2 therapy using highly degradable Mg alloys may provide an effective cancer treatment.}
}