TY  - JOUR
AU  - Chen, Qiwen
AU  - Fan, Yunhao
AU  - Dong, Shu
AU  - Han, Ping
AU  - Xie, Tian
AU  - Wang, Chenchen
AU  - Zeng, Xiaoqin
AU  - Ding, Wenjiang
AU  - Meng, Zhiqiang
AU  - Wang, Leyun
PY  - 2023
TI  - A highly degradable Mg-Al-Ca alloy with superior anti-tumor efficacy
JO  - Journal of Magnesium and Alloys
SN  - 2213-9567
SP  - 4206
EP  - 4217
VL  - 11
IS  - 11
AB  - Molecule hydrogen (H2) has been used to suppress tumor growth. To employ the H2 therapy, it is necessary to use a proper agent for continuous generation of H2. As a biodegradable metal, magnesium (Mg) generates H2 in an aqueous environment, but the H2 release rate is still too low. Here, we design a Mg-Al-Ca (AX) alloy that degrades very rapidly due to the presence of a secondary phase Al2Ca. Having a reduction potential much higher than Mg and any other Mg-based secondary phases, Al2Ca accelerates the corrosion of the Mg matrix by a micro-galvanic process. Al2Ca also enhances the strength and ductility of the AX alloy. AX alloy rods show better anti-tumor efficacy than pure Mg rods in vivo. Moreover, implanted AX alloy rods can be heated under an alternating magnetic field to suppress large-size tumors. This work suggests that the H2 therapy using highly degradable Mg alloys may provide an effective cancer treatment.
UR  - https://doi.org/10.1016/j.jma.2023.07.018
DO  - 10.1016/j.jma.2023.07.018