@article{Díez-Villanueva2025, 
author = {Pablo Díez-Villanueva and Pedro Cepas-Guillén and María Thiscal López Lluva and Alfonso Jurado-Román and Pablo Bazal-Chacón and Martín Negreira-Caamaño and Iván Olavarri-Miguel and Ane Elorriaga and Ricardo Rivera-López and David Escribano and Pablo Salinas and María Martínez-Avial and Antonio Martínez-Guisado and Clea González-Maniega and Felipe Díez-Delhoyo},
title = {One-year clinical events according to frailty in older patients  with non-ST elevation acute coronary syndrome undergoing coronary angiography: an analysis of the IMPACT-TIMING-GO study},
year = {2025},
journal = {Journal of Geriatric Cardiology},
volume = {22},
number = {1},
pages = {159-168},
url = {https://www.sciopen.com/article/10.26599/1671-5411.2025.01.003},
doi = {10.26599/1671-5411.2025.01.003},
abstract = {Objective To evaluate the prevalence and one-year prognosis associated with frailty in a contemporary cohort of older patients with non-ST-elevation acute coronary syndrome (NSTEACS). Methods The IMPACT-TIMING-GO registry (IMPACT of Time of Intervention in patients with Myocardial Infarction with Non-ST seGment elevation. ManaGement and Outcomes) prospectively included 1020 patients with NSTEACS undergoing invasive coronary angiography between April and May 2021. For this sub-study, patients ≥ 65 years were selected. Frailty was assessed according to FRAIL scale. We studied all-cause mortality and the composite of all-cause mortality or all-cause hospitalizations at one-year follow-up after discharge. Results Five hundred and sixty seven patients (mean age: 75.8 ± 6.7 years, 28.2% women) were included: 316 (55.7%) were robust, 183 (32.3%) prefrail, and 68 (12.0%) frail. Frail patients were significantly older, more often women, and presented a worse baseline clinical profile. There were no differences among groups regarding pretreatment with a P2Y12 inhibitor. An urgent angiography (< 24 h) was less frequently performed in frail patients, with no differences regarding revascularization approach or in main in-hospital adverse events, although acute kidney disease occurred more frequently in frail patients. At 1-year follow-up, 20 patients died (3.6%). Chronic kidney disease was independently associated with 1-year all-cause death, although a trend towards higher mortality was observed in frail patients (HR = 3.01; 95% CI: 0.93–9.78; P = 0.065). Frailty was independently associated with higher 1-year all-cause mortality or all-cause rehospitalizations (HR = 2.23; 95% CI: 1.43–3.46; P < 0.001) Conclusions In older patients with NSTEACS, frailty independently associates higher all-cause mortality or all-cause hospital admissions at one-year follow-up}
}