TY  - JOUR
AU  - Akbarzadeh, Fatemeh Zahra
AU  - Sarraf, Masoud
AU  - Ghomi, Erfan Rezvani
AU  - Kumar, Vishnu Vijay
AU  - Salehi, Mojtaba
AU  - Ramakrishna, Seeram
AU  - Bae, Sungchul
PY  - 2024
TI  - A state-of-the-art review on recent advances in the fabrication and characteristics of magnesium-based alloys in biomedical applications
JO  - Journal of Magnesium and Alloys
SN  - 2213-9567
SP  - 2569
EP  - 2594
VL  - 12
IS  - 7
AB  - Magnesium (Mg) and its alloys have recently gained increasing attention in the biomedical field as promising biodegradable materials with harmless degradation products. Magnesium-based alloys have a wide range of biomedical applications because of their outstanding biocompatibility and unique mechanical properties. Widespread use of Mg-based biomedical devices eliminates the need for post-healing biomaterial removal surgery and minimizes the negative consequences of the implantation of permanent biomaterials, including stress shielding and undesired metal ion release in the body. This paper provides a literature review on the properties and manufacturing methods of Mg-based alloys for biomedical applications, including orthopedic implants, cardiovascular applications, surgical wires and staplers, and antitumor activities. Each application of Mg-based biomaterials is investigated from a biological perspective, including matching functional properties, biocompatibility, host tissue responses, and anti-microbial strategies, along with potential additive manufacturing technologies for these applications. Finally, an outlook is presented to provide recommendations for Mg-based biomaterials in the future.
UR  - https://doi.org/10.1016/j.jma.2024.06.015
DO  - 10.1016/j.jma.2024.06.015