@article{Hao2026, 
author = {Wenzhi Hao and Lu Wang and Yalin Li and Yingren Zhang and Weidong Pan and Xiang Luo and Xiaoxu Zhu and Yali Huang and Nanbo Wang and Li Yan and Junqing Huang and Jiaxu Chen},
title = {Formononetin mitigates neuroinflammation-induced depressive-like behaviors via metabolic remodeling of the gut microbiota},
year = {2026},
journal = {Food Science and Human Wellness},
volume = {15},
number = {8},
pages = {9250552},
keywords = {Formononetin, Neuroinflammation, Depression, Gut microbiota, Gut-brain axis, Metabolic remodeling},
url = {https://www.sciopen.com/article/10.26599/FSHW.2025.9250552},
doi = {10.26599/FSHW.2025.9250552},
abstract = {Formononetin (FMNT), an isoflavone commonly found in medicinal and food-related plants, demonstrates promising therapeutic potential. In this study, FMNT treatment significantly improved depressive-like behaviors in rats, alleviated colonic tissue damage, and suppressed the release of peripheral lipopolysaccharide (LPS) and inflammatory factors. It also enhanced intestinal barrier function by increasing the expression of tight junction proteins (claudin-1, claudin-6, and occludin). Microbiota analysis revealed that FMNT mitigated LPS-induced dysbiosis, reducing Proteobacteria levels and restoring the Firmicutes/Bacteroidetes (F/B) ratio. At the genus level, FMNT increased the abundance of S24-7 and Lactobacillus while inhibiting Dorea. Moreover, FMNT modulated microbial metabolism by influencing pathways associated with lysine degradation, arginine biosynthesis, and steroid hormone biosynthesis, along with elevating short-chain fatty acids (SCFAs). Collectively, this study underscores FMNT’s vital role in ameliorating depressive-like symptoms triggered by neuroinflammation, primarily through the maintenance of intestinal homeostasis and the rebalancing of the gut microbiota.}
}