@article{Ouyang2024, 
author = {Sihui Ouyang and Xiong Wu and Li Meng and Xuerui Jing and Liying Qiao and Jia She and Kai Zheng and Xianhua Chen and Fusheng Pan},
title = {More than the barrier effect: Biodegradable Mg-Ag alloy membranes for guided bone/tissue regeneration},
year = {2024},
journal = {Journal of Magnesium and Alloys},
volume = {12},
number = {11},
pages = {4454-4467},
keywords = {Biodegradable, Magnesium alloy, Antibacterial, Guided tissue regeneration, Guided bone regeneration},
url = {https://www.sciopen.com/article/10.1016/j.jma.2024.03.022},
doi = {10.1016/j.jma.2024.03.022},
abstract = {Magnesium (Mg) and its alloys have emerged as promising candidates for guided bone/tissue regeneration (GBR/GTR) due to their good mechanical properties, biosafety, and biodegradability. In this study, we present a pioneering application of Mg-Ag alloys featuring tunable corrosion behaviors for GBR/GTR membranes, showcasing their in vitro antibacterial effects, cell migration, and osteogenic differentiation abilities. Mg-Ag alloys with different Ag contents were engineered to facilitate the cell migration of murine fibroblasts (L929) and the osteogenic differentiation of rat bone mesenchymal stem cells (rBMSCs). The Mg-Ag alloy consisted of recrystallized α-Mg grains and fine Mg4Ag second phases, with an observable refinement in the average grain size to 5.6 µm with increasing Ag content. Among the alloys, Mg-9Ag exhibited optimal mechanical strength and moderate plasticity (tensile yield strength of 205.7 MPa, elongation of 20.3%, and a maximum bending load of 437.2 N). Furthermore, the alloying of Ag accelerated the cathodic reaction of pure Mg, leading to a slightly increased corrosion rate of the Mg-Ag alloys while maintaining acceptable general corrosion. Notably, compared with pure Mg, Mg-Ag alloys had superior antibacterial effects against Porphyromonas gingivalis (P. gingivalis) and Staphylococcus aureus (S. aureus). Taken together, these results provide evidence for the significant clinical potential of Mg-Ag alloys as GBR/GTR membranes.}
}