@article{Liu2025, 
author = {Yongyong Liu and Kai Huang and Xiao Guan and Sen Li and Hongdong Song and Ying Zhang and Yu Zhang and Zhu Sun and Zhiquan Yu},
title = {Oat avenanthramide B alleviates high-fat diet-induced obesity via regulating fatty acid metabolism involved in gut bacteria and fungi remodeling},
year = {2025},
journal = {Food Science and Human Wellness},
volume = {14},
number = {2},
pages = {9250124},
keywords = {High-fat diet, Fatty acid metabolism, Avenanthramide B, Ileal lipid absorption, Gut bacteria and fungi},
url = {https://www.sciopen.com/article/10.26599/FSHW.2024.9250124},
doi = {10.26599/FSHW.2024.9250124},
abstract = {Oat avenanthramides (AVNs) have been found to exhibit novel lipid-lowering effects. However, the mechanism remains unclear. In this study, the effect of avenanthramide B (AVN B), as one of the major AVNs, on high-fat diet (HFD)-induced mice was investigated. Results showed that AVN B significantly inhibited weight gain and improved hepatic and serum lipid biochemical indices. Hepatic RNA-sequencing analysis suggested that AVN B significantly modulates fatty acid (FA) metabolism. Hepatic real-time qualitative polymerase chain reaction (RT-qPCR) and Western blot results indicated that AVN B could alleviate FA synthesis by activating the adenosine 5’-monophosphate (AMP)-activated protein kinase (AMPK)-sterol regulatory element binding protein-1c (SREBP1c)-fatty acid synthase (FAS), and increase FA oxidation by activating the AMPK/carnitine palmitoyltransferase 1A (CPT1A) and peroxisome proliferator-activated receptor α (PPARα). Additionally, AVN B had a regulating effect on ileum lipid metabolism by inhibiting intestinal cell differentiation and down-regulating the expression levels of FA absorption-related protein and gene. Moreover, AVN B promoted the growth of beneficial bacteria and fungi such as Coriobacteriaceae_UCG-002, Parvibacter, Enterococcus, and Aspergillus, while decreasing the abundance of Roseburia, unclassified_f_Lachnospiraceae, Cladosporium, Eurotium, unclassified_f_Aspergillaceae and unclassified_f_Ceratocystidaceae. All these results provided new points of the lipid-lowing mechanism of AVNs and oats via the gut-liver axis.}
}