@article{CHEN2024, 
author = {Danni CHEN and Sainan WANG and Zhaochun YIN and Zewen XU and Xiaomin GUO and Kangyuan LI and Jiawei WANG and Liping CHEN and Yong CAO and Suyao XIAO},
title = {Toxicity and Hypolipidemic Activity of Lansiumamide B in Mice},
year = {2024},
journal = {Food Science},
volume = {45},
number = {7},
pages = {145-154},
keywords = {lansiumamide B, no observed adverse effect level, hypolipidemic, insulin resistance, oxidative stress},
url = {https://www.sciopen.com/article/10.7506/spkx1002-6630-20230808-049},
doi = {10.7506/spkx1002-6630-20230808-049},
abstract = {Objective To explore the hypolipidemic activity and toxic side effect of lansiumamide B (LB) from chicken-heart shaped wampee (Clausena lansium) seeds in C57BL/6J mice fed on a high-fat-diet (HFD) model. Methods The no observed adverse effect level (NOAEL) of LB in mice was assessed by oral acute toxicity test. HFD-fed mice were intragastrically administered with LB at 1/100, 1/50 and 1/25 NOAEL for 4 weeks. To evaluate the lipid-lowering activity of LB, body mass, serum lipids, insulin resistance, and oxidative stress indicators were measured. Results The NOAEL of LB was 2 g/kg mb. LB significantly reduced body mass in HFD-fed mice. Compared with the HFD model group, body mass decreased by 15.51% and Lee’s index declined by 3.25% in the high-dose LB group; the concentration of high-density lipid-cholesterol (HDL-C) increased by 38.04%, and the activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT) in the serum increased by 41.86%, 41.95%, and 105.50%, respectively. Conclusion LB within the NOAEL range has significant lipid-lowering activity in mice without obvious toxicity.}
}