@article{Fan2025, 
author = {Wenrui Fan and Yuntong Chen and Mengmeng Yu and Yongzhen Liu and Yulong Gao},
title = {Advances on ALV-J in China over the past two decades},
year = {2025},
journal = {Journal of Integrative Agriculture (JIA)},
volume = {24},
number = {2},
pages = {429-440},
keywords = {subgroup J avian leucosis, epidemiology, molecular variation, pathogenicity, prevention and control},
url = {https://www.sciopen.com/article/10.1016/j.jia.2024.05.009},
doi = {10.1016/j.jia.2024.05.009},
abstract = {Avian leukosis is an important tumorigenic disease caused by the avian leukosis virus (ALV) in poultry. ALVs belong to the retroviral family and are classified into 11 subgroups (ALV-A to ALV-K). Among them, ALV-J was first introduced into China in 1999, spreading widely and evolving from infecting meat-type chickens to layer chickens and Chinese local chickens. ALV-J typically induces myeloid leukosis in infected chickens, but also induces a high proportion of hemangiomas in infected layer chickens, posing a serious threat to poultry breeds in China. As a retrovirus, the genome of ALV-J has undergone significant mutations, which may be related to the expansion of the infection host range and increased pathogenicity of ALV-J. Over the last two decades, the introduction and spread of ALV-J in China have caused substantial losses to the poultry industry. Specialized detection assays have been developed to combat ALV-J infections in China. Additionally, ongoing research aims to employ gene-editing technology as a novel antiviral strategy to control the spread of ALV infections. This review highlights the importance of understanding the impact of ALV-J on the Chinese poultry industry and emphasizes the need for ongoing research and innovation to safeguard poultry health and promote sustainable poultry farming practices in China.}
}