@article{Huang2026, 
author = {Li Huang and Jiaxin Xiao and Jie Lyu and Xinru Wei and Yunqin Zheng and Xinrui Zhao and Zewei Ma and Jiayan Xue and Xinyue Yu and Xiaolei Ze and Liang Li and Meilin Zhang and Huan Liu},
title = {Lacticaseibacillus paracasei LPB27 ameliorates depressive-like behaviors in CUMS rats by inhibiting IDO-1 and regulating tryptophan metabolism},
year = {2026},
journal = {Food Science and Human Wellness},
volume = {15},
number = {5},
pages = {9250477},
keywords = {Depression, Gut microbiota, Tryptophan metabolism, Lacticaseibacillus paracasei LPB27, Indoleamine 2,3-dioxygenase},
url = {https://www.sciopen.com/article/10.26599/FSHW.2025.9250477},
doi = {10.26599/FSHW.2025.9250477},
abstract = {It remains unclear whether probiotics could alleviate depression by regulating the tryptophan (Trp) metabolism and secretion of its metabolites via affecting indoleamine 2,3-dioxygenase (IDO-1). Therefore, this study was conducted to explore the underlying mechanism of Lacticaseibacillus paracasei LPB27 in resisting depression. The results demonstrated that LPB27 intervention improved the depressive-like behavior in rats with depression and reversed the altered microbiota and decreased inflammatory factors. LPB27 intervention down-regulated the expression of HMGB1, RAGE, and IDO-1, and regulated Trp metabolism in depression rats, manifested as elevated concentrations of 5-HT and 5-hydroxy-L-tryptophan (5-HTP) and decreased levels of L-kynurenine, kynurenate, picolinic acid, and cinnavalininate. Moreover, LPB27 also significantly increased the levels of dopamine (DA), norepinephrine (NE), glutamate (GLU), and gamma-aminobutyric acid (GABA). These results corroborated that LPB27 intervention could restore the disrupted homeostasis of certain gut microbiota, decrease the level of inflammation, HMGB1, RAGE and IDO-1, and regulate Trp metabolism, which collectively contributed to the improvement of depressive-like behavior.}
}