@article{YAO2024, 
author = {Ru YAO and Zhixin HAO and Yang QU and Chao ZHANG and Weijia LI and Jie LANG and Bo PAN and Yidong ZHOU and Qiang SUN and Li HUO},
title = {Novel 18F-FES PET/CT in Non-invasive Functional Diagnosis of Delayed Lung Metastasis Presented with Horner Syndrome in a Metastatic Breast Cancer Patient},
year = {2024},
journal = {Medical Journal of Peking Union Medical College Hospital},
volume = {15},
number = {3},
pages = {702-707},
keywords = {breast cancer, 18F-FES PET/CT, pulmonary metastasis, Horner syndrome, estrogen receptor},
url = {https://www.sciopen.com/article/10.12290/xhyxzz.2023-0530},
doi = {10.12290/xhyxzz.2023-0530},
abstract = {Hormonal receptor positive human epidermal receptor 2 negative (HR+/HER2-) is the commonest molecular subtype of breast cancer (BC). Patients with HR+/HER2- BC may manifest clinically a late recurrence whose BC metastasizes 10-15 years post-operatively. We report one case who presented with pulmonary mass in upper lobe of lung and Horner syndrome 16 years after BC surgery. FDG PET/CT suggested pulmonary malignancy but could not differentiate between primary or metastatic cancer when invasive biopsy was quite risky. Novel 18F-FES PET/CT facilitated the non-invasive functional diagnosis of estrogen-receptor positive (ER+) pulmonary metastasis of BC, and the patient experienced partial response (PR) after CDK4/6 inhibitor and aromatase inhibitor as endocrine therapy. This article reviews the diagnosis and treatment process of this case, to provide guidance for non-invasive global evaluation of ER status among metastatic HR+/HER2- BC patients with 18F-FES PET/CT.}
}