@article{SHI2024, 
author = {Qianling SHI and Hui LIU and Zijun WANG and Xufei LUO and Bingyi WANG and Nan YANG and Wenbo MENG and Yaolong CHEN},
title = {How to Correctly Understand and Use the Low-quality Evidence to Formulate Recommendations in Guidelines},
year = {2024},
journal = {Medical Journal of Peking Union Medical College Hospital},
volume = {15},
number = {3},
pages = {676-685},
keywords = {clinical practice guidelines, recommendations, quality of evidence, GRADE},
url = {https://www.sciopen.com/article/10.12290/xhyxzz.2024-0278},
doi = {10.12290/xhyxzz.2024-0278},
abstract = {The essence of clinical practice guidelines lies in their recommendations. It is common to find strong recommendations supported by low-quality evidence in current published guidelines. There is a typical misunderstanding among medical professionals that without high-quality evidence, it is impossible to develop high-quality guidelines or only expert consensus can be developed. Based on the GRADE approach, this paper explains the concept and clinical significance of low-quality evidence, and introduces the methods for formulating recommendations based on low-quality evidence in guidelines, with the aim to provide reference for guideline developers and users in China.}
}