@article{SUN2024, 
author = {Zhencan SUN and Jukun ZHOU and Yunpeng XU and Jun WANG and Ya ZHENG and Yuping WANG and Rui JI},
title = {Mechanism of Epithelial-mesenchymal Transition Leading to Gastric Cancer Induced by Helicobacter pylori},
year = {2024},
journal = {Medical Journal of Peking Union Medical College Hospital},
volume = {15},
number = {1},
pages = {160-165},
keywords = {Helicobacter pylori, epithelial-mesenchymal transition, gastric cancer, cytotoxin-associated gene A, mesenchymal stem cells},
url = {https://www.sciopen.com/article/10.12290/xhyxzz.2023-0341},
doi = {10.12290/xhyxzz.2023-0341},
abstract = {Helicobacter pylori (Hp) is a unipolar, microaerobic, multiflagellar, spiral-shaped Gram-negative bacterium that survives and colonizes human gastric mucosa. As a classⅠcarcinogen associated with gastric cancer, long-term stimulation of gastric mucosa by Hp can cause atrophic gastritis, peptic ulcer, gastric cancer and gastric mucosa-associated lymphoid tissue lymphoma. It has been reported that Hp can cause epithelial-mesenchymal transition (EMT) in gastric epithelial cells, thereby inducing gastric cancer. We review the mechanism of Hp-induced EMT in gastric epithelial cells, in order to provide new insights for early diagnosis and targeted therapy of gastric cancer.}
}