@article{Li2025, 
author = {Ziyu Li and Mingqiang Li and Xiaoguo Liu and Jielin Chen},
title = {Design, regulation, and functionalization of self-assembled DNA crystals},
year = {2025},
journal = {Nano Research},
volume = {18},
number = {7},
pages = {94907250},
keywords = {DNA nanotechnology, DNA crystallography, framework nucleic acid, self-assembled DNA crystal},
url = {https://www.sciopen.com/article/10.26599/NR.2025.94907250},
doi = {10.26599/NR.2025.94907250},
abstract = {Crystals are materials in which atoms, ions, or molecules are arranged in a periodic and ordered three-dimensional structure. Among novel crystalline nanomaterials, self-assembled DNA crystals form via the base-pair complementarity of DNA molecules. Unlike traditional ionic or metallic crystals, self-assembled DNA crystals offer high programmability, enabling the design of addressable frameworks with tunable pore sizes for host-guest interactions and further functionalization through interfacial chemical modifications. Over the past 15 years, research interest in DNA nanotechnology and DNA self-assembled nanomaterials has surged. This review provides a comprehensive overview of the design principles, regulation, and functionalization of self-assembled DNA crystals for applications in molecular recognition, catalysis, and photonic crystals, while also addressing their emerging challenges within the broader context of nucleic acid chemistry and structural DNA nanotechnology.}
}