@article{Yang2024, 
author = {Jianshe Yang},
title = {Nanoparticle-based siRNA Delivery System in Intestine Empowers the Obesity Management},
year = {2024},
journal = {Nano Biomedicine and Engineering},
volume = {16},
number = {4},
pages = {521-524},
keywords = {nanotechnology, nanoparticle, siRNA therapy, drug delivery system, obesity},
url = {https://www.sciopen.com/article/10.26599/NBE.2024.9290110},
doi = {10.26599/NBE.2024.9290110},
abstract = {We highlighted a poly lactic acid-co-glycolic acid (PLGA)-block-polyethylene glycol (PEG) and chitosan-based nanoparticle system to deliver sterol O-acyltransferase 2 (SOAT2) siRNAs into the small intestines of mice to effectively inhibit lipid uptake and tackle obesity. Intestinal SOAT2 can regulate fatty acid uptake and its inhibition can enhance ubiquitination-based CD36 degradation in the enterocytes. This work demonstrates a potential modulatory function of intestinal SOAT2 on lipid uptake, highlighting the therapeutic effect of targeting intestinal SOAT2 against obesity. It exhibits promising translational relevance in the siRNA therapeutics-based treatment for obesity.}
}