@article{Zhang2025, 
author = {Yina Zhang and Lin Lin and Zihao Wang and Yun Zhao and Li Jiang and Qiance Han and Nan Gao and Jiangtao Jia and Xiaodong Feng and Guangshan Zhu},
title = {Fast responsive drug delivery device for thermo-triggered nitric oxide release by surface modified porous frameworks},
year = {2025},
journal = {Nano Research},
volume = {18},
number = {10},
pages = {94907227},
keywords = {surface modification, drug release, transdermal delivery, nitric oxide, porous aromatic framework},
url = {https://www.sciopen.com/article/10.26599/NR.2025.94907227},
doi = {10.26599/NR.2025.94907227},
abstract = {Nitric oxide (NO) is a gaseous transmitter with a wide range of physiological functions. Herein, a transdermal patch with a non-aggressive drug delivery manner using high specific surface area porous aromatic frameworks (PAFs) as carriers is designed. With the surface-modified PAF-1, the internal hydrophobicity allows the equally hydrophobic NO donor, i.e. isoamyl nitrite (IAN), to be encapsulated into PAF-1’s pores. The external hydrophilicity allows the PAF-1 particles to be mixed well with the water-soluble polymer matrix, polyvinyl alcohol (PVA), to prepare a mixed-matrix membrane (MMM) of IAN@PAF-1-mPEG/PVA as a patch. The MMM could release the NO very fast to ~ 14.3 μM in 6 min under a simulated environment. NO could also enter the bloodstream through the mice’s skin under thermal stimulation and could increase NO concentration in the blood of mice to ~ 4.8 μM in 25 min.}
}