@article{Guo2025, 
author = {Wen-Jing Guo and Yu Zhang and Hassan Elsayed and Chang-Qin Li and Xiao-Yu Chen},
title = {Iridoid terpenoids: a class of promising compounds to regulate blood glucose},
year = {2025},
journal = {Food & Medicine Homology},
volume = {2},
number = {3},
pages = {9420074},
keywords = {diabetes, signaling pathways, mechanisms, iridoids},
url = {https://www.sciopen.com/article/10.26599/FMH.2025.9420074},
doi = {10.26599/FMH.2025.9420074},
abstract = {Iridoids derived from plants have demonstrated promising effects in regulating glycemic levels, which have captured the attention of researchers. Thus, an overview of iridoids with hypoglycemic activity, with a particular focus on their potential mechanisms of action in various cellular and animal models was summarized. It has been observed that iridoids primarily exert anti-inflammatory, antioxidant, and hypoglycemic effects through signaling pathways such as NF-κB, MAPK, AMPK, PI3K/AKT, NLRP3, ROS, NOX4, and AGEs/RAGE, thereby mitigating the symptoms of diabetes and its complications. By comprehensively summarizing and analyzing the molecular pathways through which iridoids alleviate diabetes and its complications, this review aims to establish a scientific foundation for the utilization of iridoids.}
}