@article{Tang2025, 
author = {Qi Tang and Zhen-Hua Liang and Jia-Jia Yuan and Elsayed Hassan Hussein Shaaban and Jin-Feng Wei and Zhen-Hua Liu},
title = {FER1L6 ameliorates insulin resistance by regulating GLUT4 expression},
year = {2025},
journal = {Food & Medicine Homology},
volume = {2},
number = {4},
pages = {9420070},
keywords = {insulin resistance, 3T3-L1 adipocytes, HepG2 cells, Eudesmin},
url = {https://www.sciopen.com/article/10.26599/FMH.2025.9420070},
doi = {10.26599/FMH.2025.9420070},
abstract = {Insulin resistance, a prominent characteristic of type 2 diabetes, has been extensively studied. In our investigation, we examined the effect of Eudesmin on insulin resistance in 3T3-L1 adipocytes and HepG2 cells. Additionally, we analyzed the alterations in mRNA expression in insulin-resistant HepG2 cells through transcriptomic techniques. Subsequently, we assessed the changes in mRNA expression in insulin-resistant HepG2 cells following Eudesmin treatment. Our analysis revealed 13 differentially expressed genes that were commonly observed. Notably, FER1L6 exhibited the most significant changes, with a marked upregulation in mRNA expression in insulin-resistant HepG2 cells. Consequently, we conducted functional experiments to validate the role of fer-1 like family member 6 (FER1L6). Specifically, through gene knockdown experiments, we observed a significant enhancement in glucose transporter type 4 (GLUT4) expression and an improvement in insulin resistance status in cell models. Therefore, FER1L6 emerges as a promising therapeutic target for insulin resistance.}
}