TY  - JOUR
AU  - WANG, Jiuling
AU  - DONG, Rui
AU  - RAN, Yushi
AU  - XIAO, Lang
AU  - ZHANG, Yi
AU  - WU, Yuzhang
PY  - 2023
TI  - Clinical indicators and immunological characteristics of COVID-19: a retrospective analysis of 123 cases
JO  - Journal of Army Medical University
SN  - 2097-0927
SP  - 689
EP  - 698
VL  - 45
IS  - 7
AB  - ObjectiveTo study the relevant clinical indicators and immunological characteristics of patients with different levels of Corona Virus Disease 2019（COVID-19）.MethodsA total of 123 patients with confirmed COVID-19 admitted to Wuhan Huoshenshan Hospital from February 5 to April 10, 2020 were enrolled as the study objects. According to Novel Coronavirus Pneumonia Treatment Protocol（6th Edition）, they were divided into recovery（n=69）, severe（n=45）, and death（n=9）groups. Their electronic medical records were collected, and basic data, clinical symptoms, and results of laboratory examinations were analyzed statistically. A cross-sectional study was conducted on the expression levels of serum cytokines, T cell characteristics, and PD-1 expression on T cells. All data were analyzed using GraphPad Prism 8.0 software.ResultsThere were 74 male and 49 female COVID-19 patients, with a median age of 63.94 years in this study, and among them, 79 were over 60 years old. Plasma C-reactive protein（CRP）, lactate dehydrogenase（LDH）, hydroxybutyrate dehydrogenase（HBHD）, cystatin C（CysC）, and procalcitonin（PCT）were significantly elevated in the severe disease and death groups（P<0.05）. The 2 groups also had obviously higher serum levels of IL-2, IL-6, IL-8, IL-10 and IL-17 than the recovery group（P<0.05）. The patients from the death group had the lowest peripheral blood lymphocyte count and the highest neutrophil count（P<0.05）. The expression level of PD-1 in CD4+ T cells and CD8+ T cells was notably higher in the severe and death groups than the recovery group（P<0.05）.ConclusionAge is associated with the level of COVID-19. And the levels of cytokines such as IL-6 and IL-8, decrease of T lymphocytes and exhaustion of T cell function are closely correlated with the severity of COVID-19.
UR  - https://doi.org/10.16016/j.2097-0927.202212120
DO  - 10.16016/j.2097-0927.202212120