@article{ZENG2024, 
author = {Ziyang ZENG and Yuhao LEI and Xianfeng WU and Ailin SONG and Chunyong YANG and Zhiyong YANG and Yujie LI and Bin YI},
title = {Catalpol protects hepatopulmonary syndrome rats against liver and lung injury},
year = {2024},
journal = {Journal of Army Medical University},
volume = {46},
number = {6},
pages = {587-596},
keywords = {hepatopulmonary syndrome, catalpol, TRGR5, bile acids},
url = {https://www.sciopen.com/article/10.16016/j.2097-0927.202312145},
doi = {10.16016/j.2097-0927.202312145},
abstract = {ObjectiveTo explore the protective effect of catalpol by enhancing TGR5 expression and reducing bile acid (BAs) level against liver and lung injury in rats with common bile duct ligation (CBDL).MethodsFifty male rats were randomly divided into sham-operation group (n=10), CBDL group (n=20) and catalpol group (n=20). The survival rate, arterial partial pressure of oxygen (PO2) and alveolar and arterial PO2 gradient difference [P(A-a)O2], liver function, and pathological changes in the liver and lungs. The relationship between bile acid level and TGR5 was analyzed.ResultsCatalpol ameliorated liver function damage, improved survival rate and hypoxemia induced by CBDL. It also reduced angiogenesis in the liver and lung. Meanwhile, catalpol mitigated lung injury caused by excessive BAs levels through enhancing TGR5 expression and reducing FXR expression.ConclusionThe protective effects of catalpol on CBDL lung injury caused by excessive BAs levels through enhancing TGR5 expression and reducing FXR expression.}
}