@article{ZUO2022, 
author = {Dukun ZUO and Yang LI and Taotao PENG and Huawei LIU and Guiying YANG and Zhenxin DUAN and Hong LI},
title = {Effects of controlled hypotension induced by sodium nitroprusside on regional cerebral blood flow and oxygenation in pigs},
year = {2022},
journal = {Journal of Army Medical University},
volume = {44},
number = {17},
pages = {1687-1693},
keywords = {anesthesia, controlled hypotension, sodium nitroprusside, cerebral blood flow, cerebral oxygen saturation},
url = {https://www.sciopen.com/article/10.16016/j.2097-0927.202205113},
doi = {10.16016/j.2097-0927.202205113},
abstract = {ObjectiveTo investigate the effects of controlled hypotension induced by sodium nitroprusside on regional cerebral blood flow and oxygenation in pigs.MethodsSix healthy female Landrace pigs (aged 4~6 months, weighing 22~25 kg) were included in this study. Sodium nitroprusside was used for controlled hypotension under sevoflurane anesthesia (20%, 30% and 50% lower than the baseline of mean arterial pressure or mean arterial pressure (MAP), corresponding to mild, moderate and severe hypotension, respectively). Oxygen to see (O2C), a monitoring instrument, was used to measure regional cerebral blood flow (rCBF) and regional cerebral oxygen saturation (rSO2). rCBF, rSO2, regional cerebral haemoglobin (rHb), heart rate (HR), peripheral oxygen saturation (SpO2) and incidence of cerebral hypoxia events were recorded under different MAP.ResultsrCBF was significantly correlated with MAP (r=0.793) and also obviously correlated with rSO2 (r=0.843) in the whole hypotension process. rSO2 had a linear correlation with rHb, MAP and rCBF (R2=0.853, P<0.05), respectively. And the order of their linear correlation with rSO2 is rHb>MAP>rCBF. During mild hypotension, rCBF and rSO2 were increased by 7.4% (P<0.05) and 2.5% (P<0.05), respectively compared with the baseline, and the increase of rCBF was more remarkable. During moderate hypotension, compared with the baseline, rCBF was decreased by 0.9% (P>0.05), while rSO2 was decreased by 5.8% (P<0.05). During severe hypotension, rCBF and rSO2 were decreased by 7.6% (P<0.05) and 12.1% (P<0.05) respectively, and there was no cerebral hypoxia event during mild to severe hypotension. From 5 to 15 min after drug withdrawal, both rCBF and rSO2 were increased by 8.4% and 3.7%, respectively when compared with the baseline (both P<0.05).ConclusionControlled hypotension with sodium nitroprusside is beneficial to maintain cerebral perfusion and cerebral oxygenation, but mild hypotension can cause an increase in cerebral blood flow, which is disadvantageous to patients with increased intracranial pressure.}
}