@article{Fu2025, 
author = {Quanbin Fu and Feijiao Hu and Wenyuan Tan and Qiaofeng Zhai and Juying Hou and Houshen Li and Zhiyong Hu and Yijing Li and Geoffrey I.N. Waterhouse and Shiyun Ai},
title = {Luminescent zinc porphyrinic MOF as a ratiometric fluorescence sensor for determination of tetracycline hydrochloride},
year = {2025},
journal = {Food Science and Human Wellness},
volume = {14},
number = {12},
pages = {9250322},
keywords = {Ratiometric fluorescence, Visual detection, Luminescent metal-organic framework, Tetracycline hydrochloride},
url = {https://www.sciopen.com/article/10.26599/FSHW.2024.9250322},
doi = {10.26599/FSHW.2024.9250322},
abstract = {Two-dimensional luminescent metal-organic frameworks (2D LMOFs), have garnered significant attention for their unique fluorescent properties and highly accessible active sites, yet designing these LMOFs with target-dependent fluorescence for sensing remains a challenging endeavor. Herein, a zinc tetra(4-carboxyphenyl) porphine (Zn-TCPP) LMOF was prepared and first applied to the fast and sensitive sensing of tetracycline hydrochloride (TCH). Upon TCH exposure, the signature red fluorescence of Zn-TCPP at 609 nm diminishes, accompanied by the emergence of a 520 nm peak, which were originated from photo-induced electron transfer (PET) of Zn-TCPP to TCH and inner filter effect (IFE) of TCH towards Zn-TCPP, and the triggers of Zn-TCPP on the instinct fluorescence of TCH, respectively. Notably, the I520 nm/I609 nm fluorescence intensity ratio showed good linearity over a wide range of TCH concentrations (0.1‒25 μmol/L), with a limit of detection (LOD) of 65.4 nmol/L. Additionally, the Zn-TCPP probe showed good TCH selectivity and anti-interference properties. The probe’s practicability was also validated by detecting TCH in spiked tap water, milk and chicken samples. Furthermore, test papers impregnated with the Zn-TCPP probe were prepared, allowing the visual detection of TCH with a smartphone. Results suggest the developed method is suitable for practical TCH detection.}
}