@article{Li2025, 
author = {Yilin Li and Jipeng Fan and Jiahe Peng and Yujie Zheng and Weiping Gong and Jizhou Jiang},
title = {2D S-doped g-C3N4 and V2CTx nanocomposites for ultra-sensitive electrochemical sensing uric acid},
year = {2025},
journal = {Nano Research},
volume = {18},
number = {1},
pages = {94907054},
keywords = {electrochemical detection, uric acid, S-doped g-C3N4, differential pulse voltammetry, V2CTx MXene},
url = {https://www.sciopen.com/article/10.26599/NR.2025.94907054},
doi = {10.26599/NR.2025.94907054},
abstract = {Accurate and sensitive detection of uric acid (UA) is crucial, as abnormal UA levels are often indicative of various diseases. This work introduces a straightforward electrochemical sensor utilizing a two-dimensional (2D) nanocomposite of S-doped g-C3N4 (SCN) and V2CTx MXene (SCN/V2C), which was prepared via ball milling followed by calcination. The SCN/V2C nanocomposite demonstrates superior conductivity and a reduced band gap relative to pure g-C3N4, leading to improved electrochemical performance for UA detection. Differential pulse voltammetry (DPV) measurements revealed a limit of detection (LOD) of 1 μM for UA and a linear response range spanning from 3 μM to 1 mM. Furthermore, experimental results confirmed the excellent stability of the SCN/V2C nanocomposite. Density functional theory (DFT) calculations revealed that SCN/V2C acts as a powerful electron donor, while UA functions as an efficient electron acceptor. The electron transfer between SCN/V2C and UA is significantly greater than that with other common interfering biological molecules, leading to the highest adsorption energy of UA on the SCN/V2C surface. This strong interaction accounts for the sensor’s exceptional selectivity. This newly developed sensor provides a straightforward and highly sensitive approach for the electrochemical detection of trace levels of UA in real biological samples.}
}