TY  - JOUR
AU  - Ruan, Qiang
AU  - Ding, Degang
AU  - Wang, Bin
AU  - He, Chaohong
AU  - Ren, Xuequn
AU  - Feng, Zhenhua
AU  - Pang, Zhigang
AU  - Wang, Jin
AU  - Zhang, Xiangliang
AU  - Tang, Hongsheng
AU  - Wang, Jiahong
AU  - He, Qingjun
AU  - Lei, Ziying
AU  - Liao, Quanxing
AU  - Luo, Jiali
AU  - Cui, Shuzhong
PY  - 2021
TI  - A multi-institutional retrospective study of hyperthermic plus intravesical chemotherapy versus intravesical chemotherapy treatment alone in intermediate and high risk nonmuscle-invasive bladder cancer
JO  - Cancer Biology & Medicine
SN  - 2095-3941
SP  - 308
EP  - 317
VL  - 18
IS  - 1
AB  - ObjectiveTo compare the efficacy and safety of hyperthermic intravesical chemotherapy (HIVEC) and intravesical chemotherapy (IVEC) in patients with intermediate and high risk nonmuscle-invasive bladder cancer (NMIBC) after transurethral resection.MethodsWe included 560 patients diagnosed with primary or recurrent NMIBC between April 2009 and December 2015 at 1 of 6 tertiary centers. We matched 364 intermediate or high risk cases and divided them into 2 groups: the HIVEC+IVEC group [chemohyperthermia (CHT) composed of 3 consecutive sessions followed by intravesical instillation without hyperthermia] and the IVEC group (intravesical instillation without hyperthermia). The data were recorded in the database. The primary endpoint was 2-year recurrence-free survival (RFS) in all NMIBC patients (n = 364), whereas the secondary endpoints were the assessment of radical cystectomy (RC) and 5-year overall survival (OS).ResultsThere was a significant difference in the 2-year RFS between the two groups in all patients (n = 364; HIVEC+IVEC: 82.42% vs. IVEC: 74.18%, P = 0.038). Compared with the IVEC group, the HIVEC+IVEC group had a lower incidence of RC (P = 0.0274). However, the 5-year OS was the same between the 2 groups (P = 0.1434). Adverse events (AEs) occurred in 32.7% of all patients, but none of the events was serious (grades 3–4). No difference in the incidence or severity of AEs between each treatment modality was observed.ConclusionsThis retrospective study showed that HIVEC+IVEC had a higher 2-year RFS and a lower incidence of RC than IVEC therapy in intermediate and high risk NMIBC patients. Both treatments were well-tolerated in a similar manner.
UR  - https://doi.org/10.20892/j.issn.2095-3941.2020.0125
DO  - 10.20892/j.issn.2095-3941.2020.0125