@article{Shi2024, 
author = {Jialu Shi and Yan Xu and Cheng Liu and Shizhi Wang and Jin Wang and Vijaya Raghavan},
title = {Preventive effects of Bifidobacterium lactis Probio-M8 on ovalbumin-induced food allergy in mice},
year = {2024},
journal = {Food Science and Human Wellness},
volume = {13},
number = {4},
pages = {2346-2352},
keywords = {Food allergy, Bifidobacterium lactis Probio-M8, T cell immune response, Gut microbiota},
url = {https://www.sciopen.com/article/10.26599/FSHW.2022.9250250},
doi = {10.26599/FSHW.2022.9250250},
abstract = {Food allergy is a significant public health concern globally. Certain probiotics have been found to enhance food allergy by regulating immune-microbe interactions in animal models and patients. However, the effects of Bifidobacterium lactis Probio-M8 on food allergy have not been thoroughly investigated. The present study examined the anti-allergic properties of Probio-M8, particularly in relation to immune response and gut microbiota composition. Results demonstrate that oral administration of Probio-M8 effectively mitigated the allergy symptoms triggered by ovalbumin (OVA) by ameliorating the morphological damage in the jejunum, reducing OVA-specific IgE and histamine levels in the serum, and suppressing Th2 cytokines (interleukin (IL) 4 and IL-13) while increasing Th1 cytokines (interferon (IFN) γ) and regulatory T (Treg) cytokines (IL-10 and transforming growth factor (TGF) β1) in the culture supernatants of splenic cells. Furthermore, Probio-M8 effectively altered the diversity and composition of gut microbiota, particularly the relative abundances of Akkermansia_muciniphila in OVA-induced mice. Compared to the OVA group, the Probio-M8 group showed a decrease in the relative abundance of Akkermansia_muciniphila. In conclusion, Probio-M8 demonstrates the potential to alleviate food allergy by regulating the Th1/Th2 response and modulating gut microbiota, thereby offering a novel therapeutic strategy for patients with food allergy.}
}