@article{Zhao2024, 
author = {Ze Qiang Zhao and Bo Zhi Chen and Jia Li Gan and Yun Hao Feng and Ling Liang and Lingyun Yu and Zi Yi Wang and Samin Abbaszadeh and Mohammad-Ali Shahbazi and Ruixing Yu and Xin Dong Guo},
title = {Dual-functional microneedle with programmatic regulation of macrophage for autoimmune psoriasis treatment},
year = {2024},
journal = {Nano Research},
volume = {17},
number = {8},
pages = {7436-7448},
keywords = {microneedle, psoriasis, M2 macrophage, immunoregulation},
url = {https://www.sciopen.com/article/10.1007/s12274-024-6711-5},
doi = {10.1007/s12274-024-6711-5},
abstract = {Modulating the immune microenvironment to establish sustained positive feedback within immune pathways represents a promising avenue for the treatment of autoimmunity. However, the precise and efficient delivery of therapeutic systems to the subcutaneous basal layer to modulate immune disorders is a major challenge in the treatment of autoimmune psoriasis. In this project, we introduce a dual-functional microneedle (DF-MN) designed to combine MNs with multiple release kinetics and immunotherapy, the programmed treatment is achieved through segmented design of the MN structure, realizing the unification of rapid and long-lasting treatment of autoimmune psoriasis. In vivo imaging results showed that GelMA@M-CSF showed fluorescent signals after 5 days of delivery to subcutaneous tissues, whereas HA@IL-13 showed minimal fluorescent signals after 2 days. The multistage release behavior of MNs and the diffusion mechanism of drugs were explained at the molecular level, in combination with coarse-grained molecular dynamics. Additionally, DF-MN can successfully induce macrophage reprogramming in vitro and ameliorate overall symptoms in a psoriasis mice model, suggesting that it has the potential to be an effective strategy for the treatment of psoriasis and portends to be a transformative platform for the treatment of other autoimmune diseases.}
}