@article{Yu2024, 
author = {Yiruo Yu and Duo Chen and Yanbing Yang and Quan Yuan},
title = {Recent Progress in Electrochemical Biosensors Based on DNA-functionalized Nanomaterials},
year = {2024},
journal = {Nano Biomedicine and Engineering},
volume = {16},
number = {3},
pages = {309-330},
keywords = {nanomaterials, DNA nanostructure, disease diagnosis, electrochemical biosensors},
url = {https://www.sciopen.com/article/10.26599/NBE.2024.9290071},
doi = {10.26599/NBE.2024.9290071},
abstract = {Electrochemical biosensors are characterized by rapid response, miniaturization, portability, and ease of operation. With tunable nanostructure, DNA has been comprehensively combined with electrochemical devices to design high-sensitivity and selectivity biosensors for the achievement of disease diagnosis, food safety, and environmental monitoring. In recent years, DNA-functionalized electrochemical biosensors have made significant research progress. In this article, the recent research progress of DNA-functionalized electrochemical biosensors for in vitro and in vivo disease diagnosis was reviewed. The structure and sensing principles of DNA-functionalized electrochemical biosensors were first summarized. The preparation of DNA-functionalized electrochemical biosensors based on nanomaterials was introduced in detail. Meanwhile, the latest evolution of integrated and portable DNA-functionalized electrochemical biosensors for in vitro disease diagnosis was summarized. For a further step, the construction of implantable DNA-functionalized electrochemical biosensors for in vivo and real-time disease monitoring was overviewed. Finally, the challenges and outlook of DNA-functionalized electrochemical biosensors were discussed to provide a guideline for the future development of DNA-functionalized electrochemical biosensors.}
}