@article{Wang2024, 
author = {Xiaoze Wang and Hui Wang and Jingkun Zhang and Ning Han and Wenjun Ma and Donghai Zhang and Mingshui Yao and Xianliang Wang and Yunfa Chen},
title = {Peroxidase-like active Cu-ZIF-8 with rich copper(I)-nitrogen sites for excellent antibacterial performances toward drug-resistant bacteria},
year = {2024},
journal = {Nano Research},
volume = {17},
number = {8},
pages = {7427-7435},
keywords = {antibacterial activity, reactive oxygen species (ROS), catalytic mechanism, peroxidase-like, Cu-doped ZIF-8},
url = {https://www.sciopen.com/article/10.1007/s12274-024-6699-x},
doi = {10.1007/s12274-024-6699-x},
abstract = {Bacterial pathogens pose a serious threat to human health, and there is an urgent need to develop highly effective antibacterial materials to eliminate the increasingly serious contamination of drug-resistant bacteria. Here, a Cu-doped ZIF-8 particle with unsaturated copper exhibits high peroxidase-like activity. 99.998% antibacterial efficiency against S. aureus can be achieved for 30 min at a low concentration of 50 μg·mL−1, as well as complete sterilization against E. coli (up to 8 log). 99.999% antibacterial efficiency against Methicillin-resistant Staphylococcus aureus can be achieved, performing orders of magnitude higher than Vancomycin. The mechanism shows that the unsaturated Cu-Nx sites are enzyme-like active centers, which could promote the consumption of bacteria reducing substances by H2O2, and the generated *OH further aggravates bacterial oxidative stress and membrane damage. More importantly, the oxidation activity of adsorbed oxygen species on Cu-ZIF-8 is enhanced by charge transfer and structural changes between the ligand and copper center like natural enzymes. Cu-doped ZIF-8 with peroxidase-like activity shows great potential in antibacterial application and the revealed catalytic mechanism is helpful for understanding the high antibacterial activity of nanoparticles with Cu-Nx sites.}
}