@article{Mao2024, 
author = {Lipeng Mao and Qiuyue Feng and Oscar Junhong Luo and Guobing Chen and Xiao Sean Leng},
title = {Human T cell development and aging: Remodeling throughout the lifespan},
year = {2024},
journal = {Aging Research},
volume = {2},
number = {1},
pages = {9340021},
keywords = {aging, human, lifespan, T cell development, remodeling},
url = {https://www.sciopen.com/article/10.26599/AGR.2024.9340021},
doi = {10.26599/AGR.2024.9340021},
abstract = {T cell development and remodeling during aging are crucial for immune health in late life and human healthspan. In this review, we delve into the mechanisms underlying these processes, with a focus on thymus development and involution, and their implications in immune function for older adults. We examine T cell subset development, including conventional naïve and regulatory T cells, effector and memory subsets, and unique subsets like γδ T cells, mucosal-associated invariant T (MAIT) cells, and natural killer T (NKT) cells. Our insights highlight the importance of enhancing immune function in older individuals and suggest potential strategies for overcoming the obstacles in studying T cell development and aging.}
}