@article{Yin2025, 
author = {Heng Yin and Meng Liu and Yaling Zhao and Haitao Wu and Danna Zheng and Zhenhui Guo and Ying Zhou and Shaofeng Wu and Chuanbing Chen and Lei Zhang and Shanshan Song and Yanli He and Ren Zhang},
title = {Lycii Radicis Cortex suppresses the growth of non-small cell lung cancer via enhancing the anti-tumor immunity},
year = {2025},
journal = {Food Science and Human Wellness},
volume = {14},
number = {2},
pages = {9250041},
keywords = {Lycii Radicis Cortex, Non-small cell lung cancer, PD-L1, Immune checkpoint},
url = {https://www.sciopen.com/article/10.26599/FSHW.2024.9250041},
doi = {10.26599/FSHW.2024.9250041},
abstract = {Lycii Radicis Cortex (LRC) is a medicinal and food homologous plant with various pharmacological activities, including anti-tumor effects. This study explores the anti-tumor effect of LRC on non-small cell lung cancer (NSCLC) and its molecular mechanism using mice bearing Lewis lung carcinoma cells. LRC significantly suppressed the growth of NSCLC. Besides, RNA sequencing of mice tumors and hematoxylin & eosin and immunofluorescence staining revealed that LRC promoted the infiltration of T lymphocytes, specifically GZMB+CD8+T lymphocytes, in tumor tissues. The Gene Set Enrichment Analysis of spleen RNA indicated that LRC up-regulated PD-1-downstream pathways, suggesting that LRC exerted its effects through the PD-L1/PD-1 pathway. Further experiments revealed that LRC interacted with PD-L1, blocking PD-L1/PD-1 binding and thus restoring the T cell killing activity on tumor cells. Together, these results support using LRC as healthy food to improve anti-tumor immunity in patients with NSCLC.}
}