@article{Kang2024, 
author = {Huiwen Kang and Danyang Huang and Jiaru Jing and Wei Zhang and Lei Zhang and Jingyu Wang and Ziyan Liu and Lin Han and Ziyan Wang and Lefeng Zhang and Ai Gao},
title = {Fasn involved in the nephrotoxicity induced by polystyrene nanoplastics and the intervention of melatonin through intestinal microbiota-mediated lipid metabolism disorder},
year = {2024},
journal = {Nano Research},
volume = {17},
number = {8},
pages = {7365-7375},
keywords = {melatonin, lipid metabolism, nephrotoxicity, nanoplastics, fatty acid synthase (Fasn)},
url = {https://www.sciopen.com/article/10.1007/s12274-024-6610-9},
doi = {10.1007/s12274-024-6610-9},
abstract = {Nanoplastics (NPs) can accumulate in the kidney and cause kidney injury, but the multi-organ interaction mechanism and preventive measures of kidney injury are still unclear. In this study, in vivo (60 μg/day, 42 days) and in vitro (0.4 μg/μL, 24 h) exposure models of polystyrene nanoplastics (PS-NPs, 80 nm) in mice and human kidney cortex proximal tubule epithelial cells (HK-2 cells) were established, respectively. Our study revealed that PS-NPs caused obvious pathological changes and impaired renal function in mice, which were related to lipid metabolism disorders mediated by intestinal flora. Desulfovibrionales-fatty acid synthase (Fasn)-docosahexaenoic acid (DHA) pathway may be one of the mechanisms of kidney injury in mice. Importantly, we also found that melatonin attenuates PS-NPs-induced nephrotoxicity by modulating lipid metabolism disorders (represented by DHA) and affects Fasn expression. In conclusion, our study revealed the important role of intestinal flora-mediated lipid metabolism in PS-NPs-induced nephrotoxicity and preliminarily provided potential key gene targets and effective preventive measures for PS-NPs-induced nephrotoxicity.}
}